Increased volume of distribution prolongs midazolam half-life.
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چکیده
منابع مشابه
(99m)Tc-DTPA volume of distribution, half-life and glomerular filtration rate in normal adults.
BACKGROUND AND AIM Assessment of volume of distribution (VD) and half-life (T1/2) values during glomerular filtration rate (GFR) investigations is a useful quality control check. The aim of this study was to derive reference data for VD and T1/2 and also to provide reference data for GFR from studies performed using Tc-diethylenetriaminepentaacetic acid (Tc-DTPA). METHODS This was a retrospec...
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PURPOSE OF REVIEW This review highlights recent developments in HIV-1 antibody engineering and discusses the effects of increased polyreactivity on serum half-lives of engineered antibodies. RECENT FINDINGS Recent studies have uncovered a wealth of information about the relationship between the sequences and efficacies of anti-HIV-1 antibodies through a combination of bioinformatics, structur...
متن کاملDynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.
Proprotein convertases are responsible for the endoproteolytic activation of proproteins in the secretory pathway. The most recently discovered member of this family, lymphoma proprotein convertase (LPC), is a type-I transmembrane protein. Previously, we have demonstrated that its cytoplasmic tail is palmitoylated. In this study, we have identified the two most proximal cysteine residues in the...
متن کاملSite-specific chemical modification of human serum albumin with polyethylene glycol prolongs half-life and improves intravascular retention in mice.
Human serum albumin (HSA) is used as an important plasma volume expander in clinical practice. However, the infused HSA may extravasate into the interstitial space and induce peripheral edema in treating the critical illness related to marked increase in capillary permeability. Such poor intravascular retention also demands a frequent administration of HSA. We hypothesize that increasing the mo...
متن کاملLeft Atrial Appendage Volume Increased in More Than Half of Patients with Cryptogenic Stroke
BACKGROUND Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk fa...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1990
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1990.tb03633.x